Volume 5, Issue 1, January 2019, Page: 12-14
Evaluation of Amlodipine Inhibition and Antimicrobial Effects
Ziyue Yi, Case Western Reserve University, Cleveland, United States
Zhu Pei, Hengyang Normal University, Hengyang, China
Ma Xiaoyan, Nanjing University of Chinese Medicine, Nanjing, China
Received: Feb. 19, 2019;       Accepted: Mar. 25, 2019;       Published: Apr. 15, 2019
DOI: 10.11648/j.ijpc.20190501.12      View  940      Downloads  207
Antibiotic resistant pathogens is the an urgent challenge of the medicine field. To counter these pathogens, the antibiotic assisting drugs is an ideal choice. Assisting drugs can improve the efficiency of the treatment without further induce of antibiotic resistance. Amlodipine (AML) is one of the most common generic cardiovascular drug for lowering blood pressure. In previous studies, amlodipine was suggested to have some antibiotic properties. The MIC is not very low for amlodipine against these pathogens. However, the findings imply amlodipine potential to be repurposed as assisting drug and its inhibition of β-lactamase. To further discover and verify its potential of antimicrobial drug, amlodipine was tested for β-lactamase inhibition, and its synergistic effects were investigated against methicillin-resistant Staphylococcus aureus (MRSA). The compound was found to inhibit β-lactamase mixture (3 distinct species) in broad spectrum. Cephalosporins requires high concentration (>=64 ug/ml) to inhibit MRSA; combine both amlodipine and cephalosporins, the MIC only requires 8ug/ml (4 ug/ml amlodipine + 4 ug/ml Cefuroxime) in total, with FIC lower than 0.1 for strong synergistic effect. Both enzyme assay and bacterial tests indicate amlodipine as an ideal assisting drug for antibiotics; one of the mechanism is β-lactamase inhibition.
Amlodipine, β-lactamase, MRSA, Synergic
To cite this article
Ziyue Yi, Zhu Pei, Ma Xiaoyan, Evaluation of Amlodipine Inhibition and Antimicrobial Effects, International Journal of Pharmacy and Chemistry. Vol. 5, No. 1, 2019, pp. 12-14. doi: 10.11648/j.ijpc.20190501.12
Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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