Volume 5, Issue 3, May 2019, Page: 31-35
A Review on the Properties and Uses of Paracetamol
Iwuozor Kingsley Ogemdi, Department of Pure and Industrial Chemistry, Nnamdi Azikiwe University, Awka, Nigeria
Received: Aug. 13, 2019;       Accepted: Sep. 6, 2019;       Published: Sep. 21, 2019
DOI: 10.11648/j.ijpc.20190503.12      View  37      Downloads  21
Abstract
N-acylated aromatic amines (those having an acyl group, RCO- substituted on nitrogen) are important in over-the-counter headache remedies. Over-the-counter drugs are those you may buy without a prescription. Paracetamol is virtually the sole survivor of the so-called “aniline derivatives” or “aniline analgesics” which are; acetanilide, phenacetin and paracetamol (acetaminophen). Phenacetin and paracetamol are both derivatives of acetanilide. Paracetamol which is also referred to as 4-hydroxyacetanilide or para-hydroxyacetanilide to an Industrial Chemist is an important end product as well as an important precursor used in the synthesis of some other Organic compounds. As an analgesic it has gained fame because it is readily available but then its adverse effect stands pronounced when it’s not taken in its rightful dosage or when it is taken in addition to some other food or drug. This article talks about the historical changes this important compound has undergone till date, its preparation by the chemist, some reactions it undergoes in the presence of some other precursors, its Dozage, Its adverse effect as well as its usage. This is a very helpful drug which becomes a poison in the presence of other drugs such as warfarin and care should be taken when handling this drug.
Keywords
Phenacetin, Drug-Drug Interaction, Preparation, Naphthalene, Acetanilide, Paracetamol
To cite this article
Iwuozor Kingsley Ogemdi, A Review on the Properties and Uses of Paracetamol, International Journal of Pharmacy and Chemistry. Vol. 5, No. 3, 2019, pp. 31-35. doi: 10.11648/j.ijpc.20190503.12
Copyright
Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Reference
[1]
Iloamaeke, I. M., and Iwuozor, K. O. (2018). Quality assessment of selected Paracetamol tablets sold at Bridge Head Market, Onitsha, Anambra state, Nigeria. British Journal of Pharmaceutical and Medical Research, 3 (5): 1190-1197.
[2]
B. Alfio, CNS drug reviews, 2006, 12 (3-4), 251-260.
[3]
K. Ashutosh, New Age International (P) limited, Publishers, New delhi, 2004, 83-89.
[4]
E. Frank, Royal Society of Chemistry, London, 2002, 1-13.
[5]
IARC, IARC Monograph on Paracetamol (Acetaminophen): An Updating of IARC Monographs, 1990, 1-50, 307-309.
[6]
M. Jones, and F. Carey, Norton publisher, London, 2005, 879-896.
[7]
A. K. Pryzybyl, J. Kurek, Laboratory of Organic Chemistry –Natural products and pharmaceuticals, 2013, 5-6.
[8]
N. G. Swarooparani, International Journal of Chemical and Physical Sciences, 2015, 8 (4), 289-294.
[9]
K. Toussaint, Journal of Clinical Pharmacy and Therapeutics, 2010, 4 (35), 620-626.
[10]
Iwuozor, K. O (2018). Quality assessment of selected Vitamin C tablets sold at Bridge Head Market, Onitsha. Journal of Chemical and Biomolecular Engineering, 3 (3); 47-50.
[11]
Jozwiak-Bebenista, M., and Nowak, J. Z. (2014). Paracetamol: Mechanism of Action, Applications and Safety Concern. Acta Poloniae Pharmaceutica-Drug Research, 71 (1); 11-23.
[12]
Asare-Nkansah, S., and Kwakye, J. K. Quality Evaluation of paracetamol in the Bulk, Dosage Forms and Body Fluids using the High Performance Liquid Chromatography (HPLC) technique, 19-26.
[13]
Mansour, O., Isbera, M., Mtaweg, A. (2017). Evaluation of Physical and Chemical Properties of Paracetamol (500mg) Tablets Marketed in Syria. Journal of Chemical and Pharmaceutical Sciences, 10 (3); 1309-1311.
[14]
Srabovic, M., Huremovic, M., Catovic, B., Kulic, S., and Taletovic, A. (2017). Design synthesis and crystallization of acetaminophen, 7 (1); 218-230.
[15]
Eynde, J. J. V. (2016). How Efficient is my (Medicinal) Chemistry? MDPI Journal of Pharmaceuticals, 9 (26); 1-16.
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