Volume 5, Issue 6, November 2019, Page: 68-71
Study of Rubus Idaeus Juice Ellagitannins and Its Antimicrobial Activity
Ivan Polischuk, Department of Chemistry of Natural Compounds and Nutriciology, National University of Pharmacy, Kharkiv, Ukraine
Mykola Komisarenko, Department of Pharmacognosy, National University of Pharmacy, Kharkiv, Ukraine
Taras Upyr, Department of Pharmacognosy, National University of Pharmacy, Kharkiv, Ukraine
Alla Kovaleva, Department of Pharmacognosy, National University of Pharmacy, Kharkiv, Ukraine
Andriy Komisarenko, Department of Chemistry of Natural Compounds and Nutriciology, National University of Pharmacy, Kharkiv, Ukraine
Received: Oct. 11, 2019;       Accepted: Oct. 29, 2019;       Published: Nov. 13, 2019
DOI: 10.11648/j.ijpc.20190506.11      View  45      Downloads  21
Abstract
Medicines on the basis of herbs are increasingly used for treating of many diseases, providing the following actions antimicrobial, antiviral, anticancer, anti-enzymatic and immunomodulatory. Ellagitannins are a group of polyphenolic compounds of plant origin, which exhibiting a strong antibacterial effect in virtue of their ability to form a bond with the microbial membrane. Raspberry contains a large amount of ellagitannins, so it is advisable to study their composition and content in raspberry juice, obtained in Ukraine and determine its antimicrobial activity. As raw material Ukrainian variety ‘Phenomenon’ was taken for the research. It was bred in 1991 in Kharkiv region by crossing the varieties ‘Stolichnaya’ and ‘Odarka’. Analysis of raspberry juice ellagitannins was performed by HPLC method. 4 ellagic acid derivatives were identified and their contents were established. Unbound ellagic acid (55% of all) and sanguiin H-6 (21% of all) had the highest content among them Antimicrobial activity of raspberry juice was studied by agar diffusion method. The juice showed antimicrobial activity against Staphylococcus aureus, Escherichia coli, Proteus vulgaris, Pseudomonas aeruginosa, Bacillus subtilis and Candida albicans. The antimicrobial activity of the juice was higher than the comparison drug " Chlorophyllipt " for more than twice in relation to all strains. The greatest effect was manifested relative to Staphylococcus aureus, which can be the cause of purulent-inflammatory processes in almost all human organs with severe consequences. This is especially true in connection with the increasing resistance of strains not only to traditional antibiotics, but also to new groups.
Keywords
Raspberry, Juice, Ellagitannins, Antimicrobial Activity
To cite this article
Ivan Polischuk, Mykola Komisarenko, Taras Upyr, Alla Kovaleva, Andriy Komisarenko, Study of Rubus Idaeus Juice Ellagitannins and Its Antimicrobial Activity, International Journal of Pharmacy and Chemistry. Special Issue: Drug Research: Current Insights for Search, Development and Analysis. Vol. 5, No. 6, 2019, pp. 68-71. doi: 10.11648/j.ijpc.20190506.11
Copyright
Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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