Volume 6, Issue 1, January 2020, Page: 6-10
Identification of an Active Component in Guiera senegalensis Plant Used for Healing Diabetes Wounds
Mohammed Sulieman Ali Eltoum, Scientific Laboratories (Chemistry), Sudan University of Science and Technology, Khartoum, Sudan
Ahmed Hapeepallah Adam, Scientific Laboratories (Chemistry), Sudan University of Science and Technology, Khartoum, Sudan
Hassan Alshafee Mohamed, Scientific Laboratories (Chemistry), Sudan University of Science and Technology, Khartoum, Sudan
Shomw Morwan Abody, Scientific Laboratories (Chemistry), Sudan University of Science and Technology, Khartoum, Sudan
Received: Mar. 3, 2020;       Accepted: Mar. 24, 2020;       Published: May 12, 2020
DOI: 10.11648/j.ijpc.20200601.12      View  96      Downloads  89
Abstract
The African species Ghobash (Guiera senegalensis J. F. Gmel), is a small herb found mainly in West Africa. It had wide spread used in traditional medicine. The aim of this study is to identify the bioactive ingredient responsible of healing diabetes wound. The aim was obtained using different process; first the plant crude oil was extracted using the soxhlet apparatus and two organic solvents (Chloroform and Methanol). Then the natural products present in dry plant leave were investigated by phytochemical screening analysis tests which confirm the main classes of secondary metabolites, namely terpenoids, alkaloids, flavonoids and steroides. The anti-bacterial activity test was carried out to show the bioactivities properties of the plant. The tests were positive in two types of bacteria: staphylococcus aureus and pseudomonas aeruginosa. The (GC/MS) analysis was carried out to separate and identify the components of the plant and their structures. The obtained results showed the presence of different active ingredients such as: flavonoids, alkaloids and steroids in high percentage. The expected compound responsible of healing diabetes wound was suggested to be stigmasterol.
Keywords
Guiera Senegalensis, J. F Gmel, Active Component, Healing Diabetes Wounds, Stigmasterol
To cite this article
Mohammed Sulieman Ali Eltoum, Ahmed Hapeepallah Adam, Hassan Alshafee Mohamed, Shomw Morwan Abody, Identification of an Active Component in Guiera senegalensis Plant Used for Healing Diabetes Wounds, International Journal of Pharmacy and Chemistry. Vol. 6, No. 1, 2020, pp. 6-10. doi: 10.11648/j.ijpc.20200601.12
Copyright
Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Reference
[1]
Chemistry for Pharmacy Students General, Organic and Natural Product Chemistry, Satyajit D. Sarker, University of Ulster, Coleraine, Northern Ireland, UK, Lutfun Nahar University of Ulster, Coleraine, Northern Ireland, UK [283 – 288].
[2]
Plant Resources of Tropical Africa (PROTA) http://uses.plantnet-project.org/en/Guiera_senegalensis_%28PROTA%29.
[3]
A. Jigam, O. Helmina, Akanya, E. N. Dauda and O. Emmanuel Ogbadoyi (2011). Antiplasmodial, analgesic and anti-inflammatory effects of crude Guiera senegalensis Gmel (Combretaceae) leaf extracts in mice infected with Plasmodium berghei. Journal of Pharmacognosy and Phytotherapy, 3 (10): 150-154.
[4]
E. T. Williams, J. T Barminas, J. Akinniyi, and A. William (2009). Antidiarrhoeal effects of the root extracts of Guiera senegalensis in male mice. African Journal of Pure and Applied Chemistry, 3 (8): 152-157.
[5]
A. E. A. Baragob, Abdelwahab Hassan, Maram Mohammed Algili Ismail, H. A. Samia, S. M. E. Khojali, A. O. A. Zakia, W. H. Almalki and H. E. H. FaragAlla (2013) Study of antimicrobial activities of Guiera senegalensis leaves. Research Journal of Pharmacology, 7 (3): 29-36.
[6]
J. Fiot, S. Sanon, N. Azas, V. Mahiou, O. Jansen, L. Angenot, G. Balansard, E. Oliver. (2006). Phytochemical and pharmacological study of roots and leaves of Guiera (Combretaceae). J Ethnopharmacol, 106 (2): 173-8.
[7]
P. A. Sombié, K. Konate, E. Youl, A. Y Coulibaly, M. Kiendrébéogo, M. I. Choudhary, O. G. Nacoulma (2013). GC-MS analysis and antifungal activity from galls of Guiera senegalensis J. F Gmel (Combretaceae). Journal of Applied Pharmaceutical Science, 3 (12): 006-012.
[8]
S. Y. Mohammed (2013). Quantitative phytochemical and elemental analysis of Guiera senegalensis leaf extract. Journal of Pharmacognosy and Phytotherapy, 5 (12): 204-207.
[9]
M. E. Osman, H. H. Yassen, J. D. Deng, R. O. Mustafa, S. M. Hussein (2014). General Phytochemical Screening and Antioxidant Activity of Some Sudanese Medicinal Plants including guiera senegalesis. JOURNAL OF FOREST PRODUCTS & INDUSTRIES, 3 (6): 292-295.
[10]
I. M. Osman, A. S. Mohammed, A. B. Abdalla (2014). Acaricidal properties of two extracts from Guiera senegalensis J. F. Gmel. (Combrataceae) against Hyalomma anatolicum (Acari: Ixodidae). journal of Veterinary Parasitology, 199 (3–4): 201-205.
[11]
N. K. Al Shafei, A. E. Elsha, and A. Nour (2016). Antitoxic, Antifungal and Phytochemical Analysis of Medicinal Compounds of Guiera senegalensis Leaves in Sudan. J Plant Biochem Physiol, 4: 2.
[12]
A. Adebiyi, R. Gbekele-Oluwa Ayo, J. D. Habila (2016). Phytochemical Screening and Anti-Tb Activity of Root Extracts of Guiera senegalensis (J. F. Gmel). Biology, DOI: 10.11648/j.bio.20150306.20 • Corpus ID: 53054972.
[13]
Z. M. Anka, Vijender Singh, S. N. Gimba, Gunjan Singh (2020). Antitoxic, Antifungal and Phytochemical Analysis of Medicinal Compounds of Guiera senegalensis Leaves. journal of drug Delivery &Therapeutics, 10 (2).
[14]
A. I. Dirar a, b, D. H. M. Alsaadi a, M. Wada a, M. A. Mohamed c, T. Watanabe a, H. P. Devkota (2019). Effects of extraction solvents on total phenolic and flavonoid contents and biological activities of extracts from Sudanese medicinal plants. South African Journal of Botany, 120: 261-267.
[15]
H. M. Gurama, F. M. Maude, M. U. Jibrin, O. S. Oluwatovi, A. A. Sani, M. A. Inuwa, S. Yahaya and U. P. Chikere (2020). Phytochemical Analysis, Cytotoxcity and Antifungal Activities of Guiera Senegalensis Leaves Extract Review. Chemical & Pharmaceutical Research, 2 (1): 1-4.
Browse journals by subject