Volume 6, Issue 3, May 2020, Page: 31-36
Study of Physical and Chemical Properties of Zincas and Feras and Its Influence on the Processes of Rat’s Fetus Development
Umarali Rajabov, Department of Pharmaceutical and Toxicological Chemistry, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan
Raufjon Sultonov, Department of Pharmaceutical and Toxicological Chemistry, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan
Abdurasul Sanginov, Department of Pharmaceutical and Toxicological Chemistry, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan
Savribegim Yormamadova, Department of Applied Chemistry, Avicenna Tajik National University, Dushanbe, Republic of Tajikistan
Gandjina Navruzova, Department of Pharmaceutical Technology and Biotechnology, Tajik National University, Dushanbe, Republic of Tajikistan
Received: May 6, 2020;       Accepted: Jun. 18, 2020;       Published: Jul. 17, 2020
DOI: 10.11648/j.ijpc.20200603.12      View  33      Downloads  22
Abstract
Acetylcysteine (ACC) helps people with pulmonary fibrosis and it is preferred treatment for the often deadly adult respiratory distress syndrome. ACC is a precursor in the formation of the glutathione antioxidant in the body. Compounds of zinc (II) and iron (II) with ACC and mucolytic medications play an important role in medical practice for the prevention of respiratory diseases. The present article is about determining the embryotoxicity of the new coordination compounds of Zincas and Feras, which are synthesized by the interaction of zinc (II) and iron (II) sulfates with acetylcysteine in an aqueous solution and have mucolytic properties in relation to diseases, bronchial asthma with a predominance of an infectious-dependent component of the course, chronic asthmatic bronchitis and chronic obstructive bronchitis. Daily administration of a feed or a high dose of 0.60 ml / kg inside the gastric suspension for 3 weeks to pregnant rats and the result of observation of the 13th week of life did not have a marked effect on the fetal development process. With the introduction of Feras and Zincas in a therapeutic dose for 1-3 weeks of pregnancy, the death of rat pups in the first month of life was comparable with the control values. The physical development of the offspring proceeded without any deviations from the norm. All pups were born normal, responded to external irritants well, with а good appetite and led an active lifestyle.
Keywords
Embryotoxicity, Feras, Zincas, Acetylcysteine, EPR, Conductometry
To cite this article
Umarali Rajabov, Raufjon Sultonov, Abdurasul Sanginov, Savribegim Yormamadova, Gandjina Navruzova, Study of Physical and Chemical Properties of Zincas and Feras and Its Influence on the Processes of Rat’s Fetus Development, International Journal of Pharmacy and Chemistry. Special Issue: Drug Research: Current Insights for Search, Development and Analysis. Vol. 6, No. 3, 2020, pp. 31-36. doi: 10.11648/j.ijpc.20200603.12
Copyright
Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Reference
[1]
RT patent № TJ. 913 Zincas showing mucolytic activity / Rajabov U. R., Yusufi S. J., Sanginov A. B., Sultonov R. A., Yusupov I. Kh., Nurulkhakov N. S. Registered in the state registry on July 9, 2018. Application № 1801199.
[2]
RT patent № TJ. 975 Feras with an antioxidant action / Rajabov U. R., Yusufi S. J., Sultonov R. A., Yusupov I. Kh., Navruzova G. F., Holova Sh. A., Jalilov Gh. Q., Murodova N. M. Registered in the state registry on February 12, 2019. Application № 1801251.
[3]
Rajabov U. R., Sultonov R. A., Yusupov I. Kh., Haydarov K. Kh. (2018). Synthesis and biological properties of zincas and its study by the spin label method. News of the AS RT 4 (169), 97-106.
[4]
Rajabov U. R., Sultonov R. A., Yormamadova S. G., Ruziev J. R. (2018). Physico-chemical basis for the study of coordination compounds. TNU Bulletin of natural sciences series 3, 185-189.
[5]
Rajabov U. R., Sultonov R. A., Yusufi S. J., Yusupov I. Kh., Haydarov K. Kh. (2018). The antioxidant effect of iron (II) with acetylcysteine and its study by the spin label method. AS RT reports 61 (9-10), 788–793.
[6]
Sultonov R. A., Rajabov U. R., Yusufi. S. J., Samandarov N. Y. (2019). Fficiency of medicines zincas and feras at subacute toxic (CCl4) hepatitis. Сolloquium-journal 9 (33), Część 3, (Warszawa, Polska), 76-79.
[7]
Rajabov U. R., Rahimova M. M., Yusupov Z. (2011). N. Imidazole and benzimidazole iron complexes. Natural and technical sciences 3, 63-70.
[8]
Rajabov U. P., Yormamadova S. G., Kozikhonov A. U., Rahimova R. H. (2015). Thermodynamic functions of the reactions of the formation of coordination compounds of iron (III) and iron (II) with dibazole at an ionic strength of 0.25 mol / l. News of the AS RT 1 (158), 93-98.
[9]
Kozikhonov A. U., Julaev U. N., Rajabov U. R., Mizhgon Shuhratzoda, Bobiev G. M. (2015). The study of the processes of formation of coordination compounds of zinc (II) with amino acids. AS RT reports. 58 (7), 608-614.
[10]
Ershov Y. A., Pleteneva T. V. The mechanisms of the toxic effect of inorganic compounds. - M.: Medicine, 1989. - 267 p.
[11]
Veterinary medications: reference book / Comp. L. P. Malanin [et al.]: Ed. A. D. Tretyakova. M.: Agropromizdat, 1988.
[12]
Sanotsky I. V. Methods for determining toxicity and hazard of chemicals (toxicometry) I. V. Sanatsky. Moscow: Publishing House: “Medicine”, 1979. pp. 257-259.
[13]
Rajabov U. R., Nazarova Kh. D., Yusupov Z. N. (2005). Effect of ionic strength on the formation of coordination compounds in the Fe (III) –Fe (II) –benzimidazole-water system at 298 K. AS RT reports. XLVIII. (1). 59-64.
[14]
Rajabov U. R., Yusupov Z. N., Nazarova Kh. D. (2005). The dependence of the constants of formation of the coordination compounds of Fe (III) and Fe (II) in aqueous solutions of benzimidazole on the ionic strength at 308 K. AS RT reports. XLVIII (2), 69-74.
[15]
Nazarova Kh. D., Rajabov U. R., Yusupov Z. N. (2006). Effect of temperature on the formation of coordination compounds in the Fe (III) –Fe (II) –benzimidazole – water system at an ionic strength of 0.25 mol / l. Avicenna Bulletin. 1-2, 358-363.
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