Volume 6, Issue 4, July 2020, Page: 37-40
The Potential Role of the Peptide Amphiphiles in Targeted Drug Delivery to Tumors
Fahimeh Shamsi, Biotechnology Research Centre, Semnan University of Medical Sciences, Semnan, Iran; School of Chemical and Bimolecular Engineering, University of Sydney, Sydney, Australia
Received: Jun. 27, 2020;       Accepted: Jul. 10, 2020;       Published: Aug. 4, 2020
DOI: 10.11648/j.ijpc.20200604.11      View  93      Downloads  71
Abstract
Background: Targeted drug delivery approaches are intended to increase the effectiveness of drugs by carrying large doses of chemotherapeutic agents to the cancer cells and reduce negative side effects. Self-assembly of peptides can organize molecules into stable and well-defined nanostructures being very attractive for many biomedical applications including drug delivery. Objective: The objective of the current mini-review is to investigate the self-assembly behavior of peptide amphiphiles as nanocarriers under different biological factors in the tumor microenvironment. Method: Data from a range of resources like Google Scholar, PubMed, Medline, Scopus and Elsevier, and other valued journals have been reviewed carefully. Results: Structural changes of peptide amphiphiles in response to tumor microenvironment or tumor-specific enzymes are the promising trend, allowing the development of targeted therapy with high efficiency. However, significant improvement in cytotoxicity is achieved when peptide amphiphiles are designed in such a way to respond to multiple stimuli in tumor microenvironments. Conclusion: A multi- disciplinary research area may permit both to reduce the off-target side effects of anticancer drugs and achieve triggered drug delivery at disease sites.
Keywords
Peptide Amphiphiles, Tumor Microenvironment, Targeted Delivery, Nanocarriers
To cite this article
Fahimeh Shamsi, The Potential Role of the Peptide Amphiphiles in Targeted Drug Delivery to Tumors, International Journal of Pharmacy and Chemistry. Vol. 6, No. 4, 2020, pp. 37-40. doi: 10.11648/j.ijpc.20200604.11
Copyright
Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Reference
[1]
Dadwal, A., et al., Nanoparticles as carriers for drug delivery in cancer. Artif. Cell. Nanomed. B, 2018. 46: p. 295-305.
[2]
Oberoi, H. S., et al., Nanocarriers for delivery of platinum anticancer drugs. Adv. Drug Deliv. Rev, 2013. 65 (13-14): p. 1667-1685.
[3]
Song, Z., et al., Self-assembly of peptide amphiphiles for drug delivery: the role of peptide primary and secondary structures. Biomater Sci, 2017. 5 (12): p. 2369-2380.
[4]
Shamsi, F. et al., Coster, Mimicking cell membrane-like structures on alkylated silicon surfaces by peptide amphiphiles. Mater. Chem. Phys, 2011. 130: p. 1162-1168.
[5]
Shamsi, F., Investigation of cellular response to covalent immobilization of peptide and hydrophobic attachment of peptide amphiphiles on substrates. Biochem. Eng. J, 2017. 117: p. 82-88.
[6]
Hartgerink, J. D., et al., Peptide-amphiphile nanofibers: a versatile scaffold for the preparation of self-assembling materials. PNAS, 2002. 99: p. 5133-8.
[7]
Hendricks, M. P., et al., Supramolecular Assembly of Peptide Amphiphiles. Acc. Chem. Res, 2017. 50: p. 2440-2448.
[8]
Kokkoli, E., et al., Self-assembly and applications of biomimetic and bioactive peptide-amphiphiles. Soft Matter, 2006. 2 (12): p. 1015-1024.
[9]
Habibi, N., et al., Self-assembled peptide-based nanostructures: Smart nanomaterials toward targeted drug delivery. Nano today, 2016. 11 (1): p. 41-60.
[10]
Laakkonen, P., et al., A tumor-homing peptide with a targeting specificity related to lymphatic vessels. Nat Med, 2002. 8 (7): p. 751-5.
[11]
Qin, H., et al., Tumor Microenvironment Targeting and Responsive Peptide-Based Nanoformulations for Improved Tumor Therapy. Mol Pharmacol, 2017. 92 (3): p. 219-231.
[12]
Jun, H.-W., et al., Enzyme-Mediated Degradation of Peptide-Amphiphile Nanofiber Networks. Adv. Mater, 2005. 17 (21): p. 2612-2617.
[13]
Acar, H., et al., Self-assembling peptide-based building blocks in medical applications. Adv. Drug Deliv. Rev, 2017. 110-111: p. 65-79.
[14]
Soukasene, S., et al., Antitumor Activity of Peptide Amphiphile Nanofiber-Encapsulated Camptothecin. ACS Nano, 2011. 5 (11): p. 9113-9121.
[15]
Fu, X., et al., RGD peptide-conjugated selenium nanoparticles: antiangiogenesis by suppressing VEGF-VEGFR2-ERK/AKT pathway. Nanomedicine, 2016. 12 (6): p. 1627-39.
[16]
Zhao, Y., et al., Self-assembled peptide nanoparticles as tumor microenvironment activatable probes for tumor targeting and imaging. J Control Release, 2014. 177: p. 11-9.
[17]
Palladino, P., et al., Conformation and self-association of peptide amphiphiles based on the KTTKS collagen sequence. Langmuir, 2012. 28 (33): p. 12209-15.
[18]
Webber, M. J., et al., Switching of Self-Assembly in a Peptide Nanostructure with a Specific Enzyme. Soft matter, 2011. 7 (20): p. 9665-9672.
[19]
Kisiday, J., et al., Self-assembling peptide hydrogel fosters chondrocyte extracellular matrix production and cell division: implications for cartilage tissue repair. PNAS, 2002. 99 (15): p. 9996-10001.
[20]
Law, B., et al., Peptide-based biomaterials for protease-enhanced drug delivery. Biomacromolecules, 2006. 7: p. 1261-5.
[21]
Cheng, Y.-J., et al., Multifunctional Peptide-Amphiphile End-Capped Mesoporous Silica Nanoparticles for Tumor Targeting Drug Delivery. ACS Appl. Mater, 2017. 9 (3): p. 2093-2103.
[22]
Rezler, E. M., et al., Peptide-mediated targeting of liposomes to tumor cells. Methods Mol Biol, 2007. 386: p. 269-98.
[23]
Boekhoven, J., et al., Alginate-peptide amphiphile core-shell microparticles as a targeted drug delivery system. RSC Adv, 2015. 5 (12): p. 8753-8756.
[24]
Rubert Pérez, C. M., et al., Mimicking the Bioactivity of Fibroblast Growth Factor-2 Using Supramolecular Nanoribbons. ACS Biomater- Sci Eng, 2017. 3 (9): p. 2166-2175.
[25]
Mitchell, K., et al., Suppression of integrin alpha3beta1 in breast cancer cells reduces cyclooxygenase-2 gene expression and inhibits tumorigenesis, invasion, and cross-talk to endothelial cells. Cancer Res, 2010. 70 (15): p. 6359-67.
[26]
Shamsi, F., H. Coster, and K. A. Jolliffe, Characterization of peptide immobilization on an acetylene terminated surface via click chemistry. Surf. Sci, 2011. 605 (19): p. 1763-1770.
[27]
Shamsi, F., et al., Characterization of the substructure and properties of immobilized peptides on silicon surface. Mater. Chem. Phys, 2011. 126 (3): p. 955-961.
[28]
Arap, W., et al., Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model. Science, 1998. 279: p. 377-80.
[29]
Lu, S., et al., Therapeutic Peptide Amphiphile as a Drug Carrier with ATP-Triggered Release for Synergistic Effect, Improved Therapeutic Index, and Penetration of 3D Cancer Cell Spheroids. Int J Mol Sci, 2018. 19 (9).
[30]
Sharma, G., et al., The Role of Cell-Penetrating Peptide and Transferrin on Enhanced Delivery of Drug to Brain. Int. J. Mol. Sci, 2016. 17 (6): p. 806.
[31]
Zhang, Q., et al., A pH-responsive α-helical cell penetrating peptide-mediated liposomal delivery system. Biomaterials, 2013. 34 (32): p. 7980-93.
Browse journals by subject