-
Review Article
Advances in Analytical Techniques for the Simultaneous Quantification of Azole Antifungals and Corticosteroids in Topical Formulations
Issue:
Volume 11, Issue 2, April 2025
Pages:
31-46
Received:
21 February 2025
Accepted:
4 March 2025
Published:
21 March 2025
Abstract: Background. The combination of azole antifungals and topical corticosteroids is widely used in treating inflamed superficial mycoses infections. These combinations provide both antifungal activity and anti-inflammatory effects, making them effective for managing various dermatological conditions. Objective. This review explores various quantitative analytical methods used for assessing azole antifungal and corticosteroid combinations in topical formulations. It evaluates techniques employed in studies published between 1999 and 2024, highlighting their advantages and limitations. Main ideas and results. The review examines various analytical techniques, including ultraviolet (UV) spectroscopy, high-performance liquid chromatography (HPLC), capillary zone electrophoresis (CZE), and high-performance thin-layer chromatography (HPTLC). Among these methods, HPLC was the most frequently employed, accounting for approximately 60% of published studies. While HPLC offers high sensitivity and reliability, its dependence on organic solvents and costly instrumentation presents limitations. Alternative methods such as thin-layer chromatography (TLC) and UV spectrophotometry were also widely utilized. TLC, representing about 14% of studies, was preferred for its simplicity and cost-effectiveness, while UV spectrophotometry, making up 24.5% of reported methods, was favored for its accessibility and ease of optimization. In contrast, capillary zone electrophoresis (CZE) was the least commonly used, appearing in only one study (less than 2%), despite its eco-friendly nature and procedural simplicity. Conclusion. Among the various analytical techniques reviewed, HPLC remained the most preferred method due to its accuracy and sensitivity. However, the continued use of UV spectrophotometry and TLC highlights the importance of cost-effective and accessible methods. The minimal adoption of CZE suggests an opportunity for further exploration into eco-friendly analytical alternatives.
Abstract: Background. The combination of azole antifungals and topical corticosteroids is widely used in treating inflamed superficial mycoses infections. These combinations provide both antifungal activity and anti-inflammatory effects, making them effective for managing various dermatological conditions. Objective. This review explores various quantitative...
Show More
-
Research Article
Assessment of Knowledge, Attitude and Practices Regarding Hypertension in a Rural Community
Issue:
Volume 11, Issue 2, April 2025
Pages:
47-54
Received:
9 March 2025
Accepted:
19 March 2025
Published:
31 March 2025
Abstract: Background: Hypertension is a major public health challenge globally, especially in rural communities where knowledge, attitude and practices (KAP) regarding its prevention and management are often inadequate. This study aimed to assess the knowledge, attitude and practices regarding hypertension among rural residents in Sreepur, Gazipur, Bangladesh. Methods: This descriptive cross-sectional study was conducted among 292 participants selected using convenient sampling. Data were collected through face-to-face interviews using a semi-structured questionnaire, covering demographic characteristics, hypertension awareness, knowledge of risk factors, attitudes towards treatment and practices related to hypertension management. Descriptive statistics were used for data analysis. Results: Among participants, 58.2% were female and the majorities were aged 30-39 years. About 90.4% were aware of their hypertension status and 50.3% had a family history of hypertension. While 63.7% believed antihypertensive drugs effectively control blood pressure, only 35.3% were currently on medications. Awareness of risk factors were low, only 20.9% identified hereditary, 14% identified obesity and 18.2% recognized tobacco use as risk factors. Additionally 75.7% reported using added salt in meals and 19.2% were current smokers. Regular medications adherence was reported by only 22.3% and 52.4% admitted irregular intake of antihypertensive medications. Conclusion: Despite high awareness of hypertension, there are significant gaps in knowledge, attitudes and practices related to risk factors, lifestyle modifications and medications adherence. Targeted community-based interventions, health education programs and improved access to healthcare services are essential to improve hypertension management in rural Bangladesh.
Abstract: Background: Hypertension is a major public health challenge globally, especially in rural communities where knowledge, attitude and practices (KAP) regarding its prevention and management are often inadequate. This study aimed to assess the knowledge, attitude and practices regarding hypertension among rural residents in Sreepur, Gazipur, Banglades...
Show More
-
Research Article
Identification of Functional Groups and Phytochemical of Crude Extracts of Ocimum Sauve Roots Using Molecular Absorption Spectroscopic Techniques
Dereje Ketema Beyene*
Issue:
Volume 11, Issue 2, April 2025
Pages:
55-61
Received:
16 February 2025
Accepted:
11 March 2025
Published:
10 April 2025
Abstract: Traditional medicines have been used in health maintenance, disease prevention and treatment in both developed and developing countries. From those the one is ocimum sauve. Ocimum sauve was used to treat a herps simplex traditionally in North shoa people, of Ethiopia. The main objective of the present study is to determine bioactive compounds of ocimum sauve and indicate its functional group by using Fourier Transform Infra-Red spectroscopy. The study area was North shoa district Oromia regional state of Ethiopia where thus plant specimens were collected. The root of ocimum sauve were dried in shaded region, ground into a powder and extracted with different solvents. The root crude extracts of ocimum sauve was tested for phytochemicals screening. The phytochemicals screening of the root extract of Ocimum sauve indicates that the presence of bioactive compound such as alkaloids, saponins, flavonoids, phenols, steroids, glycosides, terpenoids and tannins compounds and some functional groups are present like alcohol, alkane, alkenes, alkynes and aromatic compounds functional groups. This plant is used in North shoa society, Oromia regional state of Ethiopia to treat herpes simplex. The result of this work supplements the traditional knowledge of the people for the traditional medicinal uses of this plant. Further research is recommended to isolate and identify pure compounds of different parts of this plant.
Abstract: Traditional medicines have been used in health maintenance, disease prevention and treatment in both developed and developing countries. From those the one is ocimum sauve. Ocimum sauve was used to treat a herps simplex traditionally in North shoa people, of Ethiopia. The main objective of the present study is to determine bioactive compounds of oc...
Show More
