Regulation of the Contractile Activity of the Small Intestine Isolated Segment in Vitro
Ruslan Valerievich Savchuk,
Dmitriy Aleksandrovich Zhukovsky,
Natalya Vladimirovna Shmatkova
Issue:
Volume 3, Issue 5, September 2017
Pages:
62-66
Received:
29 May 2017
Accepted:
5 September 2017
Published:
17 October 2017
Abstract: Radical cystectomy with urine derivation in the segment of the small intestine is the "gold standard" for the treatment of muscle-invasive bladder cancer. The main method of urine derivation, providing the best quality of life for the patient, is an orthotopic bladder formed from the ileal segment of the intestine. The aim of study was to examine the effect of new chemical compounds on the contractile activity of the ileal wall of mini-pigs in vitro. Pyrrole-2-carbaldehyde 3- (dimethylamino) benzoylhydrazone and 1-methylisatin N, N-dimethylcarbamylhydrazone are two compounds with the greatest constrictor activity. Such compounds in concentration of 1×10-3 mol / l, increase the contractile activity on 54.3 ± 9.2% and 51.2 ± 3.1%, the amplitude of contractions on 59.01 ± 12%, and 49.18 ± 14%, the frequency of reductions on 47.9 ± 6.4 % and 31.3 ± 5.3%. Pyrrole-2-carbaldehyde 2-hydroxybenzoylhydrazone and isatin benzoylhydrazone reduce hypertonicity on 49.6 ± 3.8% and respectively on 39.6% ± 3.1%. Pyrrole-2-carbaldehyde 2-hydroxybenzoylhydrazone and isatin benzoylhydrazone are the two compounds that reduce hypertonicity on 49.6 ± 3.8% and 39.6% ± 3.1%, making antispasmodic effect with tropicity to ileum.
Abstract: Radical cystectomy with urine derivation in the segment of the small intestine is the "gold standard" for the treatment of muscle-invasive bladder cancer. The main method of urine derivation, providing the best quality of life for the patient, is an orthotopic bladder formed from the ileal segment of the intestine. The aim of study was to examine t...
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Effect of Trace Elements from Consumption of Crops Cultivated on Mine Domes (Spoils): A Case Study of Jos Plateau and Environs, Central Nigeria
Raymond Revelation Dakar,
Umaru Umaru Nahabu,
Adamu Yunusa Ugya,
Tijjani Sabiu Imam
Issue:
Volume 3, Issue 5, September 2017
Pages:
67-71
Received:
30 May 2017
Accepted:
26 August 2017
Published:
26 October 2017
Abstract: The study was conducted on the Jos Plateau metropoly and its environs in Jos North, parts of Jos South and Barkin-Ladi Local Government Areas of Plateau State, Central Nigeria. The studied area covered south eastern part of Naraguta sheet 168 NE, extends down North eastern part of Kurra sheet 189NE bounded by Longitude 8˚50΄E to 9˚00΄E and Latitude 9˚ 26΄N to 9˚43΄N respectively. This area sampled covers a land mass of about 586.25 square kilometer. This study begins from May, 2009 to March, 2016 at the National Veterinary Research Institute (NVRI), Vom. The aim was to investigate the effect of trace elements from consumption of crops cultivated on mine domes (spoils). The results presented in this paper refer to Tomato and Irish-potato, which are the most popular crops planted in that area in 2009-2016 respectively. Energy Dispersive X-Ray Fluorescence spectrometry(ED-XRFS) method was employed for the analysis of Cu, Fe, Zn, Ni, Pb, Cr and Mn. This study concluded that all those concentrations are well below threshold limit values accepted in Nigeria. No significant differences in Cu, Pb and Cr concentrations between the tested Tomato and Irish-potato were found. Zinc concentration in Potato was significantly lower than in Irish potato. Generally, the study concluded that plant samples were found to have major, minor and mostly trace elements’ concentrations below the safe values. However, Pb that has high concentration above the safe value (threshold limit) in Potato is advised not to be cultivated around mine domes, because of its health adverse effects on the inhabitants.
Abstract: The study was conducted on the Jos Plateau metropoly and its environs in Jos North, parts of Jos South and Barkin-Ladi Local Government Areas of Plateau State, Central Nigeria. The studied area covered south eastern part of Naraguta sheet 168 NE, extends down North eastern part of Kurra sheet 189NE bounded by Longitude 8˚50΄E to 9˚00΄E and Latitude...
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