First Line Anti-tuberculosis Medication for Pregnant Women
Issue:
Volume 8, Issue 2, March 2022
Pages:
20-23
Received:
31 December 2021
Accepted:
22 January 2022
Published:
14 April 2022
Abstract: Tuberculosis is more sophisticated to diagnose in pregnant women contract the diseases because tuberculosis clinical manifestations suchlike tiredness, difficulty of breathing, sweating, weakness, coughing, and rare body temperature that is higher than normal are identical to the physiology of pregnant women changed during pregnancy. According to the United States food and drug administration risk classification of medicines among pregnancy; the four first line anti-tuberculosis medications are classified as category B and category C. The 1st line regimen management for pulmonary and extrapulmonary tuberculosis does not distinctive during pregnant and nonpregnant women. The WHO recommends 8 weeks of isoniazid, rifampicin, pyrazinamide, and ethambutol for intensive phase, followed by 16 weeks of isoniazid and rifampicin for continuation phase. This regimen is safe to use during pregnancy. Rifampicin is a category C medicine. Bleeding differentiated to hypoprothrominemia has been reported in child less than 1 year and mother following the usage of rifampicin in pregnancy period begins at 28 weeks until birth. The usage of rifampicin is recommended for pregnant women with vitamin K for management tuberculosis, should be given to the breastfeeding women and the child less than 1 year postnatal if rifampicin is given to the pregnant mother in the last few weeks. Ethambutol is pregnancy class B medicine. Ethambutol highly concentrated in fetus plasma concentration which can be as high as thirty percent of the plasma concentration of drugs in mother because ethambutol easily crosses the placental barrier. Ethambutol freely crosses the placenta with a cord to maternal serum ratio of 0.75.
Abstract: Tuberculosis is more sophisticated to diagnose in pregnant women contract the diseases because tuberculosis clinical manifestations suchlike tiredness, difficulty of breathing, sweating, weakness, coughing, and rare body temperature that is higher than normal are identical to the physiology of pregnant women changed during pregnancy. According to t...
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