Synthesis of Novel Pyrimido Pyrimidine and Their Derivatives
Sirsat Shivraj Balajirao,
Jadhav Anilkumar Govindrao,
Nilesh B Chavhan
Issue:
Volume 6, Issue 1, January 2020
Pages:
1-5
Received:
18 March 2020
Accepted:
1 April 2020
Published:
30 April 2020
Abstract: Chalcone derivatives were synthesis by the reaction of some 4-nitrobenzaldehyde derivatives with acotophenone then the product obtained E-3-(4-nitrophenyl)-1-phenylprop-2-en-1-one. This product is chalcone is another react with guanidine nitrate. The hetrocyclic derivatives of guanidine nitrate respectively the final product have been characterized by elemental analysis. the product obtained is 1,6 dihydro 6(4-nitrophenyl) 4-phenylpyridine 2-amine. In present report novel pyrimidines were prepared from starting materials chalcone and guanidine nitrate. The resulting compound 1,6-dihydro-6-(4-nitrophenyl)-4 phenylpyrimidin 2 amine (2) was further reacted with 2 bis(methylthio)methylene malononitrile in the presence of catalytic amount of potassium carbonate in DMF under reflux condition that offered novel 4,6,9,9a-tetrahydro-4-imino-2-(methylthio)-8-(4-nitrophenyl) 6 phenyl 1H pyrimido[1,2 a]pyrimidine 3 carbonitrile (3). The synthesized compounds were characterized by spectral methods. The compound (3) possesses replaceable methylthio (-SCH3) group at 2 position. The compound (3) react with various nucleophiles like substituted aromatic amines, aromatic phenols, hetryl amines and active methylene compounds to give 4,6,9,9a-tetrahydro-4-imino-2-(methylthio)-8-(4-nitrophenyl)-6-phenyl-1H-pyrimido[1,2-a]pyrimidine-3-carbonitrile –carbonitrile in good yields.
Abstract: Chalcone derivatives were synthesis by the reaction of some 4-nitrobenzaldehyde derivatives with acotophenone then the product obtained E-3-(4-nitrophenyl)-1-phenylprop-2-en-1-one. This product is chalcone is another react with guanidine nitrate. The hetrocyclic derivatives of guanidine nitrate respectively the final product have been characterized...
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Identification of an Active Component in Guiera senegalensis Plant Used for Healing Diabetes Wounds
Mohammed Sulieman Ali Eltoum,
Ahmed Hapeepallah Adam,
Hassan Alshafee Mohamed,
Shomw Morwan Abody
Issue:
Volume 6, Issue 1, January 2020
Pages:
6-10
Received:
3 March 2020
Accepted:
24 March 2020
Published:
12 May 2020
Abstract: The African species Ghobash (Guiera senegalensis J. F. Gmel), is a small herb found mainly in West Africa. It had wide spread used in traditional medicine. The aim of this study is to identify the bioactive ingredient responsible of healing diabetes wound. The aim was obtained using different process; first the plant crude oil was extracted using the soxhlet apparatus and two organic solvents (Chloroform and Methanol). Then the natural products present in dry plant leave were investigated by phytochemical screening analysis tests which confirm the main classes of secondary metabolites, namely terpenoids, alkaloids, flavonoids and steroides. The anti-bacterial activity test was carried out to show the bioactivities properties of the plant. The tests were positive in two types of bacteria: staphylococcus aureus and pseudomonas aeruginosa. The (GC/MS) analysis was carried out to separate and identify the components of the plant and their structures. The obtained results showed the presence of different active ingredients such as: flavonoids, alkaloids and steroids in high percentage. The expected compound responsible of healing diabetes wound was suggested to be stigmasterol.
Abstract: The African species Ghobash (Guiera senegalensis J. F. Gmel), is a small herb found mainly in West Africa. It had wide spread used in traditional medicine. The aim of this study is to identify the bioactive ingredient responsible of healing diabetes wound. The aim was obtained using different process; first the plant crude oil was extracted using t...
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